Lightning Talk GENEMAPPERS 2026

Patch clamp data improves variant classification and penetrance stratification in SCN5A-Brugada Syndrome (#19)

Joanne Ma 1 2 , Matthew O’Neill 3 4 , Jessa Aldridge 5 , Joseph Solus 5 , Genevieve Harvey 5 , Paige Roberson 5 , Julien Barc 6 7 , Connie Bezzina 6 8 , Dan Roden 5 9 , Roddy Walsh 8 10 , Jamie Vandenberg 1 2 , Andrew Glazer 5 , Chai-Ann Ng 1 2
  1. Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
  2. School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, NSW, Australia
  3. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
  4. Department of Medicine, Harvard Medical School, Boston, MA, USA
  5. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
  6. European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, The Netherlands
  7. Nantes Université, l'institut du thorax, Nantes, France
  8. Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands
  9. Departments of Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
  10. Cardiovascular and Genomics Research Institute, St. George’s University of London, London, UK
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